Encoding of cutaneous stimuli by lamina I projection neurons.

ABSTRACT:

Abstract

Lamina I of the dorsal horn, together with its main output pathway, lamina I projection neurons, has long been implicated in the processing of nociceptive stimuli, as well as the development of chronic pain conditions. However, the study of lamina I projection neurons is hampered by technical challenges, including the low throughput and selection biases of traditional electrophysiological techniques. Here we report on a technique that uses anatomical labelling strategies and in vivo imaging to simultaneously study a network of lamina I projection neurons in response to electrical and natural stimuli. Although we were able to confirm the nociceptive involvement of this group of cells, we also describe an unexpected preference for innocuous cooling stimuli. We were able to c

SUBMITTER: Chisholm KI 

PROVIDER: S-EPMC8374708 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature