Efficacy of ketamine in relieving neuropathic pain: a systematic review and meta-analysis of animal studies.

ABSTRACT:

Abstract

In humans, proof of long-term efficacy of ketamine treatment in neuropathic pain is lacking. To improve our understanding of ketamine behavior under various administration conditions, we performed a systematic review and meta-analyses of controlled studies on the efficacy of ketamine in mice and rats with a disease model of nerve injury on relief of allodynia. Searches in PubMed and EMBASE identified 31 unique studies. Four meta-analyses were conducted. The first analysis included 19 comparisons on a single ketamine dose and measurement of effect within 3 hours of dosing and showed an appreciable effect (standardized mean difference 1.6, 95% confidence interval 1.1-2.1). Subgroup analyses showed no effect of species, administration route, or dose. A single administration w

SUBMITTER: Velzen MV 

PROVIDER: S-EPMC8374709 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature