Phenotypic Consequences of the GJD2 Risk Genotype in Myopia Development.

ABSTRACT:

Purpose

To study the relatively high effect of the refractive error gene GJD2 in human myopia, and to assess its relationship with refractive error, ocular biometry and lifestyle in various age groups.

Methods

The population-based Rotterdam Study (RS), high myopia case-control study MYopia STudy, and the birth-cohort study Generation R were included in this study. Spherical equivalent (SER), axial length (AL), axial length/corneal radius (AL/CR), vitreous depth (VD), and anterior chamber depth (ACD) were measured using standard ophthalmologic procedures. Biometric measurements were compared between GJD2 (rs524952) genotype groups; education and environmental risk score (ERS) were calculated to estimate gene-environment interaction effects, using the Synergy index (SI).

Re

SUBMITTER: Haarman AEG 

PROVIDER: S-EPMC8375003 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature