Intratumoral regulatory T cells from colon cancer patients comprise several activated effector populations.

ABSTRACT:

Background

Intratumoral regulatory T cells (Treg) in colon cancer are a heterogeneous cell population, with potential impact on patient outcome. Generally, a high Treg infiltration has been correlated to a worse patient outcome, but it is still unclear how the composition of different Treg subsets affects patient relapse and survival. In this study, we used mass and flow cytometry to characterize Treg in colon tumors and corresponding unaffected tissue, followed by a correlation to clinical parameters and patient outcome.

Results

Using mass cytometry, we defined 13 clusters of intestinal Treg, three of which were enriched in the tumors. The two most enriched clusters were defined by their expression of the proliferation marker Ki67 and CD56, respectively. The Treg accumulati

SUBMITTER: Szeponik L 

PROVIDER: S-EPMC8375143 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature