Thyroid-related ophthalmopathy development in concurrence with growth hormone administration.

ABSTRACT:

Background

Thyroid stimulating hormone (TSH) receptor and local infiltrate lymphocytes have been considered as major pathological factors for developing thyroid-related ophthalmopathy. Overexpression of insulin-like growth factor-I (IGF-I) receptor has emerged as a promising therapeutic target for refractory patients. However, the relationship between activation of growth hormone (GH)/IGF-I receptor signaling and development or exacerbation of thyroid ophthalmopathy has not been elucidated. Herein we describe a case that provides further clarification into the association between thyroid-related ophthalmopathy and GH/IGF-I receptor signaling.

Case presentation

A 62-year-old Japanese female diagnosed with thyroid-related ophthalmopathy was admitted to Kurume University Hospit

SUBMITTER: Iwata S 

PROVIDER: S-EPMC8375170 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature