Diagnosis of early stage knee osteoarthritis based on early clinical course: data from the CHECK cohort.

ABSTRACT:

Background

Early diagnosis of knee osteoarthritis (OA) is important in managing this disease, but such an early diagnostic tool is still lacking in clinical practice. The purpose of this study was to develop diagnostic models for early stage knee OA based on the first 2-year clinical course after the patient's initial presentation in primary care and to identify whether these course factors had additive discriminative value over baseline factors.

Methods

We extracted eligible patients' clinical and radiographic data from the CHECK cohort and formed the first 2-year course factors according to the factors' changes over the 2 years. Clinical expert consensus-based diagnosis, which was made via evaluating patients' 5- to 10-year follow-up data, was used as the outcome factor. F

SUBMITTER: Wang Q 

PROVIDER: S-EPMC8375192 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature