Acute pharmacogenetic dystonic reactions in a family with the CYP2D6 *41 allele: a case report.

ABSTRACT:

Background

Dystonia is a known neurological complication of certain medications; however, the mechanism behind such effects is often undetermined. Similarly, the clinical pharmacogenomic effects associated with various alleles of the cytochrome P450 family of proteins, and their role in acute dystonic reactions, are also presently unknown.

Case presentation

We describe a woman presenting with acute dystonic reactions to ondansetron, prochlorperazine, and metoclopramide followed by persistent focal dystonia. A similar family history was reported in her siblings and her father to prochlorperazine, drugs all metabolized by the cytochrome P450 2D6 (CYP2D6) enzyme. Pharmacogenomic testing indicated the patient was heterozygous for the intermediate metabolizer *41 allele (CYP2D6 2

SUBMITTER: Wong DY 

PROVIDER: S-EPMC8375217 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature