A TIMM17A Regulatory Network Contributing to Breast Cancer.

ABSTRACT:

Background

Translocase of inner mitochondrial membrane 17A (TIMM17A) is overexpressed in breast cancer (BRCA), and upregulation can increase the aggressiveness of BRCA cells. This study examined the influence of the TIMM17A gene network on BRCA outcome.

Methods

Expression levels of TIMM17A were compared between normal and tumor tissues from the Oncomine^TM database, and the association with patient survival was analyzed using Kaplan-Meier Plotter. Clinical factors influencing TIMM17A expression were studied by UALCAN. cBioPotal was then used to identify genes interacting with TIMM17A, and network relationships were assessed using the R clusterProfiler package. The association between TIMM17A mutation and mRNA expression in

SUBMITTER: Cai J 

PROVIDER: S-EPMC8375323 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature