Neuropeptide Y (NPY) and posttraumatic stress disorder (PTSD): A translational update.

ABSTRACT: Posttraumatic stress disorder (PTSD) is a trauma-evoked syndrome, with variable prevalence within the human population due to individual differences in coping and resiliency. In this review, we discuss evidence supporting the relevance of neuropeptide Y (NPY), a stress regulatory transmitter in PTSD. We consolidate findings from preclinical, clinical, and translational studies of NPY that are of relevance to PTSD with an attempt to provide a current update of this area of research. NPY is abundantly expressed in forebrain limbic and brainstem areas that regulate stress and emotional behaviors. Studies in rodents demonstrate a role for NPY in stress responses, anxiety, fear, and autonomic regulation, all relevant to PTSD symptomology. Genetic studies support an association of NPY polymorphi

SUBMITTER: Schmeltzer SN 

PROVIDER: S-EPMC8375392 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature