Thalamic volume mediates associations between cardiorespiratory fitness (VO₂max) and cognition in Parkinson's disease.

ABSTRACT:

Introduction

Cognitive deficits occur in Parkinson's disease (PD). Cardiorespiratory fitness (CRF) is associated with better cognitive performance in aging especially in executive function (EF) and memory. The association between CRF and cognitive performance is understudied in people with PD. Brain structures underlying associations also remains unknown. This cross-sectional study examined the associations between CRF and cognitive performance in PD. We also examined associations between CRF and brain structures impacted in PD. Mediation analysis were conducted to examine whether brain structures impacted in PD mediate putative associations between CRF and cognitive performance.

Methods

Individuals with PD (N = 33) underwent magnetic resonance imaging (MRI), CRF evaluation

SUBMITTER: Petkus AJ 

PROVIDER: S-EPMC8375572 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature