Induced Pluripotent Stem Cells in Psychiatry: An Overview and Critical Perspective.

ABSTRACT: A key challenge in psychiatry research is the development of high-fidelity model systems that can be experimentally manipulated to explore and test pathophysiological mechanisms of illness. In this respect, the emerging capacity to derive neural cells and circuits from human induced pluripotent stem cells (iPSCs) has generated significant excitement. This review aims to provide a critical appraisal of the potential for iPSCs in illuminating pathophysiological mechanisms in the context of other available technical approaches. We discuss the selection of iPSC phenotypes relevant to psychiatry, the information that researchers can draw on to help guide these decisions, and how researchers choose between the use of 2-dimensional cultures and the use of more complex 3-dimensional model systems.

SUBMITTER: De Los Angeles A 

PROVIDER: S-EPMC8375580 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature