Developmental Profile of Psychiatric Risk Associated With Voltage-Gated Cation Channel Activity.

ABSTRACT:

Background

Recent breakthroughs in psychiatric genetics have implicated biological pathways onto which genetic risk for psychiatric disorders converges. However, these studies do not reveal the developmental time point(s) at which these pathways are relevant.

Methods

We aimed to determine the relationship between psychiatric risk and developmental gene expression relating to discrete biological pathways. We used postmortem RNA sequencing data (BrainSeq and BrainSpan) from brain tissue at multiple prenatal and postnatal time points, with summary statistics from recent genome-wide association studies of schizophrenia, bipolar disorder, and major depressive disorder. We prioritized gene sets for overall enrichment of association with each disorder and then tested the relationsh

SUBMITTER: Clifton NE 

PROVIDER: S-EPMC8375582 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature