Modern Acinetobacter baumannii clinical isolates replicate inside spacious vacuoles and egress from macrophages.

ABSTRACT: Multidrug-resistant Acinetobacter baumannii infections are increasing at alarming rates. Therefore, novel antibiotic-sparing treatments to combat these A. baumannii infections are urgently needed. The development of these interventions would benefit from a better understanding of this bacterium's pathobiology, which remains poorly understood. A. baumannii is regarded as an extracellular opportunistic pathogen. However, research on Acinetobacter has largely focused on common lab strains, such as ATCC 19606, that have been isolated several decades ago. These strains exhibit reduced virulence when compared to recently isolated clinical strains. In this work, we demonstrate that, unlike ATCC 19606, several modern A. baumannii clinical isolates, including the recent clinical urinary isolate UPA

SUBMITTER: Sycz G 

PROVIDER: S-EPMC8376066 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature