PPIDomainMiner: Inferring domain-domain interactions from multiple sources of protein-protein interactions.

ABSTRACT: Many biological processes are mediated by protein-protein interactions (PPIs). Because protein domains are the building blocks of proteins, PPIs likely rely on domain-domain interactions (DDIs). Several attempts exist to infer DDIs from PPI networks but the produced datasets are heterogeneous and sometimes not accessible, while the PPI interactome data keeps growing. We describe a new computational approach called "PPIDM" (Protein-Protein Interactions Domain Miner) for inferring DDIs using multiple sources of PPIs. The approach is an extension of our previously described "CODAC" (Computational Discovery of Direct Associations using Common neighbors) method for inferring new edges in a tripartite graph. The PPIDM method has been applied to seven widely used PPI resources, using as "Gold-Sta

SUBMITTER: Alborzi SZ 

PROVIDER: S-EPMC8376228 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature