Effect of HIV and Interpersonal Trauma on Cortical Thickness, Cognition, and Daily Functioning.

ABSTRACT:

Background

Interpersonal trauma (IPT) is highly prevalent among HIV-positive (HIV+) individuals, but its relationship with brain morphology and function is poorly understood.

Setting

This cross-sectional analysis evaluated the associations of IPT with cognitive task performance, daily functioning, magnetic resonance imaging (MRI) brain cortical thickness, and bilateral volumes of 4 selected basal ganglia regions in a US-based cohort of aviremic HIV+ individuals, with (HIV+ IPT+) and without IPT exposure (HIV+ IPT-), and sociodemographically matched HIV-negative controls with (HIV- IPT+) and without IPT exposure (HIV- IPT-).

Methods

Enrollees completed brain MRI scans, a semistructured psychiatric interview, a neurocognitive battery, and 3 measures of daily functioning

SUBMITTER: Kapetanovic S 

PROVIDER: S-EPMC8376232 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature