Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome.

ABSTRACT: Maintenance of immune homeostasis involves a synergistic relationship between the host and the microbiome. Canonical interferon (IFN) signaling controls responses to acute microbial infection, through engagement of the STAT1 transcription factor. However, the contribution of tonic levels of IFN to immune homeostasis in the absence of acute infection remains largely unexplored. We report that STAT1 KO mice spontaneously developed an inflammatory disease marked by myeloid hyperplasia and splenic accumulation of hematopoietic stem cells. Moreover, these animals developed inflammatory bowel disease. Profiling gut bacteria revealed a profound dysbiosis in the absence of tonic IFN signaling, which triggered expansion of T_H17 cells and loss of splenic T_reg cells. Reduction o

SUBMITTER: Marie IJ 

PROVIDER: S-EPMC8376249 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature