The Prognostic Value and Function of HOXB5 in Acute Myeloid Leukemia.

ABSTRACT:

Background

Currently, cytogenetic and genetic markers are the most important for risk stratification and treatment of patients with acute myeloid leukemia (AML). Despite the identification of many prognostic factors, relatively few have made their way into clinical practice. Therefore, the identification of new AML biomarkers is useful in the prognosis and monitoring of AML and contributes to a better understanding of the molecular basis of the disease. Homeobox (HOX) genes are transcription factors that lead to cell differentiation blockade and malignant self-renewal. However, the roles of HOX genes in AML are still not fully understood and need further exploration, which may provide new strategies for the prognosis and monitoring of AML.

Methods

We analyzed the RNA sequenc

SUBMITTER: Chen M 

PROVIDER: S-EPMC8376581 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature