Relationships of sleep disturbance, intestinal microbiota, and postoperative pain in breast cancer patients: a prospective observational study.

ABSTRACT:

Purpose

Our study was designed to examine the possible relationship between gut microbiota, sleep disturbances, and acute postoperative pain.

Methods

Using 16S rRNA sequencing, we analyzed preoperative fecal samples from women undergoing breast cancer surgery. Preoperative sleep disturbance was evaluated with the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Peak and average pain at rest and movement were evaluated 24 h after surgery, using a numerical rating scale (NRS). Preoperative symptoms of depression and anxiety were assessed with the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7), respectively. Inflammation was measured using white blood cell and neutrophil counts, together with platelet-lymphocyte ratio, and neutrophil-lymph

SUBMITTER: Yao ZW 

PROVIDER: S-EPMC8376716 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature