LncRNA SNHG20 promotes cell proliferation and invasion by suppressing miR-217 in ovarian cancer.

ABSTRACT:

Background

Ovarian cancer is the most common female gynecological malignancy. SNHG20, as a long non-coding RNA, has been proven to be an important regulator in the occurrence and development of various tumors. However, the potential mechanism of SNHG20 in ovarian cancer is unclear.

Objective

The present study was aimed to investigate the functions and mechanisms of SNHG20 in ovarian cancer.

Methods

The expression of SNHG20 and miR-217 in ovarian cancer tissues and cell lines was detected by qRT-PCR. CCK-8 assay was used to measure cell proliferation in transfected cells. The transwell assay was used to detect the relative invasion rate of transfected cells. The putative binding sites between SNHG20 and miR-217 were predicted by software LncBase v.2, and the interactio

SUBMITTER: Xing X 

PROVIDER: S-EPMC8376724 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature