A quantitative approach for measuring laterality in clinical fMRI for preoperative language mapping.

ABSTRACT:

Purpose

fMRI is increasingly used for presurgical language mapping, but lack of standard methodology has made it difficult to combine/compare data across institutions or determine the relative efficacy of different approaches. Here, we describe a quantitative analytic framework for determining language laterality in clinical fMRI that addresses these concerns.

Methods

We retrospectively analyzed fMRI data from 59 patients who underwent presurgical language mapping at our institution with identical imaging and behavioral protocols. First, we compared the efficacy of different regional masks in capturing language activations. Then, we systematically explored how laterality indices (LIs) computed from these masks vary as a function of task and activation threshold. Finally, we

SUBMITTER: Olaru M 

PROVIDER: S-EPMC8376727 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature