Human histamine H₂ receptors can initiate cardiac arrhythmias in a transgenic mouse.

ABSTRACT: Histamine is known to lead to arrhythmias in the human heart. A mouse model to mimic these effects has hitherto not been available but might be useful to study the mechanism(s) of H₂-histamine receptor-induced arrhythmias and may support the search for new antiarrhythmic drugs. In order to establish such a model in mice, we studied here the incidence of cardiac arrhythmias under basal and under stimulated conditions in atrial and ventricular preparations from mice that overexpressed the human H₂-histamine receptors in a cardiac-specific way (H₂-TG) in comparison with their wild-type (WT) littermate controls. We had shown before that histamine exerted concentration and time-dependent positive inotropic and positive chronotropic effects only in cardiac prepar

SUBMITTER: Gergs U 

PROVIDER: S-EPMC8376741 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature