Genetic correlates of socio-economic status influence the pattern of shared heritability across mental health traits.

ABSTRACT: Epidemiological studies show high comorbidity between different mental health problems, indicating that individuals with a diagnosis of one disorder are more likely to develop other mental health problems. Genetic studies reveal substantial sharing of genetic factors across mental health traits. However, mental health is also genetically correlated with socio-economic status (SES), and it is therefore important to investigate and disentangle the genetic relationship between mental health and SES. We used summary statistics from large genome-wide association studies (average N ~ 160,000) to estimate the genetic overlap across nine psychiatric disorders and seven substance use traits and explored the genetic influence of three different indicators of SES. Using genomic structural equation mo

SUBMITTER: Marees AT 

PROVIDER: S-EPMC8376746 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature