Longitudinal Change in Quality of Life in Neurological Disorders Measures Over 3 Years in Patients with Early Parkinson's Disease.

ABSTRACT:

Background

The Quality of Life in Neurological Disorders (Neuro-QoL) is a publicly available health-related quality-of-life measurement system.

Objective

The aim of this study was to evaluate the utility of Neuro-QoL item banks as outcome measures for clinical trials in Parkinson's disease.

Methods

An analysis of Neuro-QoL responsiveness to change and construct validity was performed in a multicenter clinical trial cohort.

Results

Among 310 participants over 3 years, changes in five of eight Neuro-QoL domains were significant (P < 0.05) but very modest. The largest effect sizes were seen in the cognition and mobility domains (0.35-0.39). The largest effect size for change over the year in which levodopa was initiated was -0.19 for lower extremity function-mobil

SUBMITTER: Marras C 

PROVIDER: S-EPMC8376764 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature