Accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloading.

ABSTRACT: During duration spaceflight, or after their return to earth, astronauts have often suffered from gait instability and cerebellar ataxia. Here, we use a mouse model of hindlimb unloading (HU) to explore a mechanism of how reduced hindlimb burden may contribute to motor deficits. The results showed that these mice which have experienced HU for 2 weeks exhibit a rapid accumulation of formaldehyde in the gastrocnemius muscle and fastigial nucleus of cerebellum. The activation of semicarbazide-sensitive amine oxidase and sarcosine dehydrogenase induced by HU-stress contributed to formaldehyde generation and loss of the abilities to maintain balance and coordinate motor activities. Further, knockout of formaldehyde dehydrogenase (FDH^-/-) in mice caused formaldehyde accumulation in the

SUBMITTER: Yao D 

PROVIDER: S-EPMC8376875 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature