Cannabinoid receptor 2 deletion influences social memory and synaptic architecture in the hippocampus.

ABSTRACT: Although the cannabinoid receptor 2 (CB₂R) is often thought to play a role mainly outside the brain several publications unequivocally showed the presence of CB₂R on hippocampal principal neurons. Activation of CB₂R produced a long-lasting membrane potential hyperpolarization, altered the input/output function of CA2/3 principal neurons and produced alterations in gamma oscillations. However, other cellular, molecular and behavioral consequences of hippocampal CB₂R signaling have not been studied in detail. Here we demonstrate that the deletion of CB₂ leads to a highly significant increase in hippocampal synapsin-I expression levels and particle density, as well as increased vesicular GABA transporter (vGAT) levels. This phenotype was

SUBMITTER: Komorowska-Muller JA 

PROVIDER: S-EPMC8376893 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature