Classification of the Gut Microbiota of Patients in Intensive Care Units During Development of Sepsis and Septic Shock.

ABSTRACT: The gut microbiota of intensive care unit (ICU) patients displays extreme dysbiosis associated with increased susceptibility to organ failure, sepsis, and septic shock. However, such dysbiosis is difficult to characterize owing to the high dimensional complexity of the gut microbiota. We tested whether the concept of enterotype can be applied to the gut microbiota of ICU patients to describe the dysbiosis. We collected 131 fecal samples from 64 ICU patients diagnosed with sepsis or septic shock and performed 16S rRNA gene sequencing to dissect their gut microbiota compositions. During the development of sepsis or septic shock and during various medical treatments, the ICU patients always exhibited two dysbiotic microbiota patterns, or ICU-enterotypes, which could not be explained by host p

SUBMITTER: Liu W 

PROVIDER: S-EPMC8377022 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature