In vivo anticancer effects of Momordica charantia seed fat on hepatocellular carcinoma in a rat model.

ABSTRACT:

Background

Momordica charantia or bitter melon is a well-known vegetable with a number of therapeutic actions in Ayurvedic medicine. Alpha-eleostearic acid, a conjugated trienoic fatty acid present in bitter melon is proven to have anticancer properties. Crude seed oil from local bitter melon varieties could be an effective and economical anticancer therapy.

Objective(s)

The study was conducted to evaluate the anticancer effect of the crude oil from the seeds of Matale green variety of bitter melon on a hepatocellular carcinoma-induced rat model.

Materials and methods

Hepatocellular carcinoma (HCC) was experimentally induced in Wistar rats. Crude seed oil of Matale green bitter melon (MGBM) was supplemented to one treatment group in concurrence with carcinoma inductio

SUBMITTER: Ranasinghe KNK 

PROVIDER: S-EPMC8377176 | biostudies-literature | 2021 Jul-Sep

REPOSITORIES: biostudies-literature