Exploring Potential Signals of Selection for Disordered Residues in Prokaryotic and Eukaryotic Proteins.

ABSTRACT: Intrinsically disordered proteins (IDPs) are an important class of proteins in all domains of life for their functional importance. However, how nature has shaped the disorder potential of prokaryotic and eukaryotic proteins is still not clearly known. Randomly generated sequences are free of any selective constraints, thus these sequences are commonly used as null models. Considering different types of random protein models, here we seek to understand how the disorder potential of natural eukaryotic and prokaryotic proteins differs from random sequences. Comparing proteome-wide disorder content between real and random sequences of 12 model organisms, we noticed that eukaryotic proteins are enriched in disordered regions compared to random sequences, but in prokaryotes such regions are dep

SUBMITTER: Panda A 

PROVIDER: S-EPMC8377245 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature