Evaluation of commercial SARS-CoV-2 serological assays in Canadian public health laboratories.

ABSTRACT: The COVID-19 pandemic has led to the influx of immunoassays for the detection of antibodies towards severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the global market. The Canadian Public Health Laboratory Network Serology Task Force undertook a nationwide evaluation of twelve laboratory and 6 point-of-care based commercial serological assays for the detection of SARS-CoV-2 antibodies. We determined that there was considerable variability in the performance of individual tests and that an orthogonal testing algorithm should be prioritized to maximize the accuracy and comparability of results across the country. The manual enzyme immunoassays and point-of-care tests evaluated had lower specificity and increased coefficients of variation compared to automated enzyme immunoas

SUBMITTER: Stein DR 

PROVIDER: S-EPMC8377389 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature