Vitamin D Level and Vitamin D Receptor Genetic Variation Were Involved in the Risk of Non-Alcoholic Fatty Liver Disease: A Case-Control Study.

ABSTRACT:

Background

It has been demonstrated that vitamin D receptor (VDR), a key gene in the metabolism of vitamin D (VD), may affect the development of Non-alcoholic fatty liver disease (NAFLD) by regulating VD level and its biological effects.

Objectives

To investigate the effects of serum VD level, VDR variation, and a combination of VDR SNP and environmental behavior factor on the risk of NAFLD.

Methods

A total of 3023 subjects from a community in Nanjing were enrolled, including 1120 NAFLD cases and 1903 controls. Serum 25(OH)D₃ levels were measured and eight single nucleotide polymorphisms (SNPs) in VDR gene were genotyped.

Results

Logistic regression analyses indicated that VD sufficiency and VD insufficiency were significa

SUBMITTER: Zhang R 

PROVIDER: S-EPMC8377425 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature