Gene expression correlates of advanced epigenetic age and psychopathology in postmortem cortical tissue.

ABSTRACT: Psychiatric stress has been associated with accelerated epigenetic aging (i.e., when estimates of cellular age based on DNA methylation exceed chronological age) in both blood and brain tissue. Little is known about the downstream biological effects of accelerated epigenetic age on gene expression. In this study we examined associations between DNA methylation-derived estimates of cellular age that range from decelerated to accelerated relative to chronological age ("DNAm age residuals") and transcriptome-wide gene expression. This was examined using tissue from three post-mortem cortical regions (ventromedial and dorsolateral prefrontal cortex and motor cortex, n = 97) from the VA National PTSD Brain Bank. In addition, we examined how posttraumatic stress disorder (PTSD) and alcoho

SUBMITTER: Wolf EJ 

PROVIDER: S-EPMC8377489 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature