Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging.

ABSTRACT:

Introduction

Higher energetic costs for mobility predict gait speed decline. Slow gait is linked to cognitive decline and Alzheimer's disease (AD). Whether the energetic cost of walking is linked to AD pathology is unknown. We investigated the cross-sectional association between the energetic cost of walking, gait speed, and amyloid beta (Aβ) status (+/-) in older adults.

Methods

One hundred forty-nine cognitively normal adults (56% women, mean age 77.5 ± 8.4 years) completed customary-paced walking assessments with indirect calorimetry and ¹¹C-Pittsburgh compound B positron emission tomography. Logistic regression models examined associations adjusted for demographics, body composition, comorbid conditions, and apolipoprotein E ε4.

Results

Each 0.01 mL/kg/

SUBMITTER: Dougherty RJ 

PROVIDER: S-EPMC8377776 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature