Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus.

ABSTRACT:

Background

Gestational diabetes mellitus (GDM) is a serious public health issue affecting 9-15% of all pregnancies worldwide. Recently, it has been suggested that extracellular vesicles (EVs) play a role throughout gestation, including mediating a placental response to hyperglycaemia. Here, we investigated the EV-associated miRNA profile across gestation in GDM, assessed their utility in developing accurate, multivariate classification models, and determined the signaling pathways in skeletal muscle proteome associated with the changes in the EV miRNA profile.

Methods

Discovery: A retrospective, case-control study design was used to identify EV-associated miRNAs that vary across pregnancy and clinical status (i.e. GDM or Normal Glucose Tolerance, NGT). EVs were isolated from

SUBMITTER: Nair S 

PROVIDER: S-EPMC8377872 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature