Vincristine induced neurotoxicity in children who underwent chemotherapy for acute lymphoblastic leukemia and Wilms tumor.

ABSTRACT:

Background & objectives

Vincristine has been used as chemotherapeutic agent for many decades. It implements its function by inhibiting the duplication of tumor cells by destroying the DNA. However, like all other drugs, its administration is not without any side effects. The most important of these are being the neurotoxic side effects. This study evaluated the degree of neurotoxicity induced by vincristine in children who underwent chemotherapy for acute lymphoblastic leukemia and Wilms tumor.

Methods

A quasi experimental study was conducted at Children Hospital & the Institute of Child Health, Multan from January 2020 to October 2020 after taking informed written consent. In this study, 150 children of age group 1 - 12 years with pathological confirmation of acute lymphobl

SUBMITTER: Adil MK 

PROVIDER: S-EPMC8377900 | biostudies-literature | 2021 Sep-Oct

REPOSITORIES: biostudies-literature