Effect of age on brain metabotropic glutamate receptor subtype 5 measured with [¹⁸F]FPEB PET.

ABSTRACT:

Objective

Metabotropic glutamate receptor subtype 5 (mGluR5) is integral to the brain glutamatergic system and cognitive function. This study investigated whether aging is associated with decreased brain mGluR5 availability.

Methods

Cognitively normal participants (n = 45), aged 18 to 84 years, underwent [¹⁸F]FPEB positron emission tomography scans to quantify brain mGluR5. Distribution volume (V_T) was computed using a venous or arterial input function and equilibrium modeling from 90 to 120 min. In the primary analysis, the association between age and V_T in the hippocampus and association cortex was evaluated using a linear mixed model. Exploratory analyses assessed the association between age and V_T in multiple brain regions. The

SUBMITTER: Mecca AP 

PROVIDER: S-EPMC8378132 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature