Multilocus sequence typing of azole-resistant Candida auris strains, South Africa.

ABSTRACT:

Background

Candida auris is an emerging multidrug-resistant fungal pathogen associated with high mortality.

Methods

We investigated the genetic relatedness of clinical C. auris isolates from patients admitted to either public- or private-sector hospitals, which were submitted to a reference laboratory from 2012 to 2015. Patient demographics and clinical details were recorded. We performed antifungal susceptibility testing, sequencing of the hotspot 1 and 2 regions of the FKS1 and FKS2 genes for all isolates with an echinocandin minimum inhibitory concentration (MIC) of ≥1 µg/mL and cluster analysis using multilocus sequence typing.

Results

Eighty-five isolates were confirmed as C. auris. The median patient age was 59 years [inter-qua

SUBMITTER: Magobo R 

PROVIDER: S-EPMC8378186 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature