Conditioned open-label placebo for opioid reduction after spine surgery: a randomized controlled trial.

ABSTRACT:

Abstract

Placebo effects have traditionally involved concealment or deception. However, recent evidence suggests that placebo effects can also be elicited when prescribed transparently as "open-label placebos" (OLPs), and that the pairing of an unconditioned stimulus (eg, opioid analgesic) with a conditioned stimulus (eg, placebo pill) can lead to the conditioned stimulus alone reducing pain. In this randomized control trial, we investigated whether combining conditioning with an OLP (COLP) in the immediate postoperative period could reduce daily opioid use and postsurgical pain among patients recovering from spine surgery. Patients were randomized to COLP or treatment as usual, with both groups receiving unrestricted access to a typical opioid-based postoperative analgesic regimen

SUBMITTER: Flowers KM 

PROVIDER: S-EPMC8378225 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature