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Genetic Diversity Analysis of Surface-Related Antigen (SRA) in Plasmodium falciparum Imported From Africa to China.


ABSTRACT: Plasmodium falciparum surface-related antigen (SRA) is located on the surfaces of gametocyte and merozoite and has the structural and functional characteristics of potential targets for multistage vaccine development. However, little information is available regarding the genetic polymorphism of pfsra. To determine the extent of genetic variation about P. falciparum by characterizing the sra sequence, 74 P. falciparum samples were collected from migrant workers who returned to China from 12 countries of Africa between 2015 and 2019. The full length of the sra gene was amplified and sequenced. The average pairwise nucleotide diversities (π) of P. falciparum sra gene was 0.00132, and the haplotype diversity (Hd) was 0.770. The average number of nucleotide differences (k) for pfsra was 3.049. The ratio of non-synonymous (dN) to synonymous (dS) substitutions across sites (dN/dS) was 1.365. Amino acid substitutions of P. falciparum SRA could be categorized into 35 unique amino acid variants. Neutrality tests showed that the polymorphism of PfSRA was maintained by positive diversifying selection, which indicated its role as a potential target of protective immune responses and a vaccine candidate. Overall, the ability of the N-terminal of PfSRA antibodies to evoke inhibition of merozoite invasion of erythrocytes and conserved amino acid at low genetic diversity suggest that the N-terminal of PfSRA could be evaluated as a vaccine candidate against P. falciparum infection.

SUBMITTER: Yang B 

PROVIDER: S-EPMC8378275 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Genetic Diversity Analysis of Surface-Related Antigen (SRA) in <i>Plasmodium falciparum</i> Imported From Africa to China.

Yang Bo B   Liu Hong H   Xu Qin-Wen QW   Sun Yi-Fan YF   Xu Sui S   Zhang Hao H   Tang Jian-Xia JX   Zhu Guo-Ding GD   Liu Yao-Bao YB   Cao Jun J   Cheng Yang Y  

Frontiers in genetics 20210805


<i>Plasmodium falciparum</i> surface-related antigen (SRA) is located on the surfaces of gametocyte and merozoite and has the structural and functional characteristics of potential targets for multistage vaccine development. However, little information is available regarding the genetic polymorphism of <i>pfsra</i>. To determine the extent of genetic variation about <i>P. falciparum</i> by characterizing the <i>sra</i> sequence, 74 <i>P. falciparum</i> samples were collected from migrant workers  ...[more]

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