Digital Peripheral Arterial Tonometry and Cardiovascular Disease Events: The Framingham Heart Study.

ABSTRACT:

Background and purpose

Novel noninvasive measures of vascular function are emerging as subclinical markers for cardiovascular disease (CVD) and may be useful to predict CVD events. The purpose of our prospective study was to assess associations between digital peripheral arterial tonometry (PAT) measures and first-onset major CVD events in a sample of FHS (Framingham Heart Study) participants.

Methods

Using a fingertip PAT device, we assessed pulse amplitude in Framingham Offspring and Third Generation participants (n=3865; mean age, 55±14 years; 52% women) at baseline and in 30-second intervals for 4 minutes during reactive hyperemia. The PAT ratio (relative hyperemia index) was calculated as the post-to-pre occlusion pulse signal ratio in the occluded arm, relative to the

SUBMITTER: Cooper LL 

PROVIDER: S-EPMC8378441 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature