Cognition-Mortality Associations Are More Pronounced When Estimated Jointly in Longitudinal and Time-to-Event Models.

ABSTRACT: With aging populations worldwide, there is growing interest in links between cognitive decline and elevated mortality risk-and, by extension, analytic approaches to further clarify these associations. Toward this end, some researchers have compared cognitive trajectories of survivors vs. decedents while others have examined longitudinal changes in cognition as predictive of mortality risk. A two-stage modeling framework is typically used in this latter approach; however, several recent studies have used joint longitudinal-survival modeling (i.e., estimating longitudinal change in cognition conditionally on mortality risk, and vice versa). Methodological differences inherent to these approaches may influence estimates of cognitive decline and cognition-mortality associations. These effects

SUBMITTER: Aichele S 

PROVIDER: S-EPMC8378533 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature