Evaluation of the ability of the trypsin-like peptidase activity assay to detect severe periodontitis.

ABSTRACT:

Objectives

N-benzoyl-DL-arginine peptidase (trypsin-like peptidase) is specifically produced by certain strains of periodontitis-associated bacteria. We aimed to examine the effectiveness of an objectively quantified trypsin-like peptidase activity assay (TLP-AA) for detecting severe periodontitis.

Methods

The study population included 347 adults (108 men and 239 women; average age, 43.3 years) who underwent a full-mouth periodontal examination. Specimens for the TLP-AA were obtained using tongue swabs. Using a color reader, the TLP-AA results were obtained as a* values, with higher positive a* values indicating an increased intense enzymatic activity. The predictive validity of the TLP-AA results for severe periodontitis was assessed using receiver operating characteristic

SUBMITTER: Iwasaki M 

PROVIDER: S-EPMC8378714 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature