M⁶A Modification Mediates Mucosal Immune Microenvironment and Therapeutic Response in Inflammatory Bowel Disease.

ABSTRACT: Accumulating evidence links m⁶A modification with immune infiltration. However, the correlation and mechanism by which m⁶A modification promotes intestinal immune infiltration in inflammatory bowel disease (IBD) is unknown. Here, genomic information from IBD tissues was integrated to evaluate disease-related m⁶A modification, and the correlation between the m⁶A modification pattern and the immune microenvironment in the intestinal mucosa was explored. Next, we identified hub genes from the key modules of the m⁶Acluster and analyzed the correlation among the hub genes, immune infiltration, and therapy. We found that IGF2BP1 and IGF2BP2 expression was decreased in Crohn's disease (CD) tissues and that IGF2BP2 was decreased in ulcerative

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8378837 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature