Molecular Landscape for Malignant Transformation in Diffuse Astrocytoma.

ABSTRACT: Background  Malignant transformation (MT) of low-grade gliomas changes dramatically the natural history to poor prognosis. Currently, factors associated with MT of gliomas have been inconclusive, in particular, diffuse astrocytoma (DA). Objective  The present study aimed to explore the molecular abnormalities related to MT in the same patients with different MT stages. Methods  Twelve specimens from five DA patients with MT were genotyped using next-generation sequencing (NGS) to identify somatic variants in different stages of MT. We used cross-tabulated categorical biological variables and compared the mean of continuous variables to assess for association with MT. Results  Ten samples succussed to perform NGS from one male and four females, with ages ranging

SUBMITTER: Tunthanathip T 

PROVIDER: S-EPMC8378925 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature