Comparing the Therapeutic Potential of Stem Cells and their Secretory Products in Regenerative Medicine.

ABSTRACT: Cell therapy involves the transplantation of human cells to replace or repair the damaged tissues and modulate the mechanisms underlying disease initiation and progression in the body. Nowadays, many different types of cell-based therapy are developed and used to treat a variety of diseases. In the past decade, cell-free therapy has emerged as a novel approach in regenerative medicine after the discovery that the transplanted cells exerted their therapeutic effect mainly through the secretion of paracrine factors. More and more evidence showed that stem cell-derived secretome, i.e., growth factors, cytokines, and extracellular vesicles, can repair the injured tissues as effectively as the cells. This finding has spurred a new idea to employ secretome in regenerative medicine. Despite that,

SUBMITTER: Foo JB 

PROVIDER: S-EPMC8378970 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature