Placental histopathology after SARS-CoV-2 infection in pregnancy: a systematic review and meta-analysis.

ABSTRACT:

Objective

This study aimed to report the spectrum of placental pathology findings in pregnancies complicated by SARS-CoV-2 infection.

Data sources

MEDLINE, Embase, Google Scholar, and the Web of Science databases were searched up to August 11, 2021.

Study eligibility criteria

Histopathologic anomalies included maternal vascular malperfusion, fetal vascular malperfusion, acute inflammatory pathology, chronic inflammatory pathology, increased perivillous fibrin, and intervillous thrombosis. Moreover, subanalyses of symptomatic women only and high-risk pregnancies were performed.

Methods

Histopathologic analysis of the placenta included gross examination, histopathology on hematoxylin and eosin, immunohistochemistry, fluorescence in situ hybridization, quantitativ

SUBMITTER: Di Girolamo R 

PROVIDER: S-EPMC8379009 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature