Spectrum of Protein Location in Proteomes Captures Evolutionary Relationship Between Species.

ABSTRACT: The native subcellular location (also referred to as localization or cellular compartment) of a protein is the one in which it acts most frequently; it is one aspect of protein function. Do ten eukaryotic model organisms differ in their location spectrum, i.e., the fraction of its proteome in each of seven major cellular compartments? As experimental annotations of locations remain biased and incomplete, we need prediction methods to answer this question. After systematic bias corrections, the complete but faulty prediction methods appeared to be more appropriate to compare location spectra between species than the incomplete more accurate experimental data. This work compared the location spectra for ten eukaryotes: Homo sapiens (human), Gorilla gorilla (gorilla), Pan troglodytes (chimpan

SUBMITTER: Marot-Lassauzaie V 

PROVIDER: S-EPMC8379119 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature