Insula activity in resting-state differentiates bipolar from unipolar depression: a systematic review and meta-analysis.

ABSTRACT: Symptomatic overlap of depressive episodes in bipolar disorder (BD) and major depressive disorder (MDD) is a major diagnostic and therapeutic problem. Mania in medical history remains the only reliable distinguishing marker which is problematic given that episodes of depression compared to episodes of mania are more frequent and predominantly present at the beginning of BD. Resting-state functional magnetic resonance imaging (rs-fMRI) is a non-invasive, task-free, and well-tolerated method that may provide diagnostic markers acquired from spontaneous neural activity. Previous rs-fMRI studies focused on differentiating BD from MDD depression were inconsistent in their findings due to low sample power, heterogeneity of compared samples, and diversity of analytical methods. This meta-analysis

SUBMITTER: Pastrnak M 

PROVIDER: S-EPMC8379217 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature