Ginsenoside Rb1 alleviates colitis in mice via activation of endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 signaling pathway.

ABSTRACT: Endoplasmic reticulum (ER) homeostasis is regulated by ER-resident E3 ubiquitin ligase Hrd1, which has been implicated in inflammatory bowel disease (IBD). Ginsenoside Rb1 (GRb1) is the major ginsenoside in ginseng with multiple pharmacological activities. In this study we investigated the role of Hrd1 in IBD and its regulation by GRb1. Two mouse colitis models were established to mimic human IBD: drinking water containing dextran sodium sulfate (DSS) as well as intra-colonic infusion of 2, 4, 6-trinitrobenzene sulfonic acid (TNBS). Colitis mice were treated with GRb1 (20, 40 mg·kg^-1·d^-1, ig) or a positive control drug sulfasalazine (500 mg·kg^-1·d^-1, ig) for 7 days. The model mice showed typical colitis symptoms and pathological changes in colon

SUBMITTER: Dong JY 

PROVIDER: S-EPMC8379258 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature