A systems biology model of junctional localization and downstream signaling of the Ang-Tie signaling pathway.

ABSTRACT: The Ang-Tie signaling pathway is an important vascular signaling pathway regulating vascular growth and stability. Dysregulation in the pathway is associated with vascular dysfunction and numerous diseases that involve abnormal vascular permeability and endothelial cell inflammation. The understanding of the molecular mechanisms of the Ang-Tie pathway has been limited due to the complex reaction network formed by the ligands, receptors, and molecular regulatory mechanisms. In this study, we developed a mechanistic computational model of the Ang-Tie signaling pathway validated against experimental data. The model captures and reproduces the experimentally observed junctional localization and downstream signaling of the Ang-Tie signaling axis, as well as the time-dependent role of receptor T

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8379279 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature