Targeted and intracellular delivery of protein therapeutics by a boronated polymer for the treatment of bone tumors.

ABSTRACT: The treatment of malignant bone tumors by chemotherapeutics often receives poor therapeutic response due to the specific physiological bone environment, and thus calls for the development of new therapeutic options. Here, we reported a bone-targeted protein nanomedicine for this purpose. Saporin, a toxin protein, was co-assembled with a boronated polymer for intracellular protein delivery, and the formed nanoparticles were further coated with an anionic polymer poly (aspartic acid) to shield the positive charges on nanoparticles and provide the bone targeting function. The prepared ternary complex nanoparticles showed high bone accumulation both in vitro and in vivo, and could reverse the surface charge property from negative to positive after locating at tumor site triggered

SUBMITTER: Yan Y 

PROVIDER: S-EPMC8379369 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature